Implement Business Logic on Lead Disqualify

Whenever you disqualify the lead it save the Lead form, so you can have  JS registered on save event to check if user initiated action to disqualify lead

In this case you need to check for savemode() equal to 15 on save event of lead

In the save event you can use the execution context object getEventArgs method to retrieve an object that contains methods you can use to manage the save event.

execObj.getEventArgs().getSaveMode()

Entity
Event Mode
Value

All

Save

1


All

Save and Close

2


All

Save and New

59


All

AutoSave

70


Activities

Save as Completed

58


All

Deactivate

5


All

Reactivate

6


User or Team owned entities

Assign

47


Email (E-mail)

Send

7


Lead

Qualify

16


Lead

Disqualify

15

Source: 
https://msdn.microsoft.com/en-us/library/gg509060(v=crm.6).aspx






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